ObGyn Intelligence: The Evidence of Women’s Health

ObGyn Intelligence: The Evidence of Women’s Health

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The “Paleo-Preeclampsia” Hypothesis: Did a Pregnancy Complication Kill the Neanderthals?

Did Preeclampsia kill the Neanderthalers?

Amos Grünebaum, MD's avatar
Amos Grünebaum, MD
Mar 13, 2026
∙ Paid

A provocative new paper in the Journal of Reproductive Immunology (2026) suggests that the extinction of Neanderthals may have been accelerated by a lack of the “safety mechanism” that protects modern Homo sapiens from lethal preeclampsia. While both species shared the exceptionally deep, energy-demanding placentation required to grow large brains, the …

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