ObGyn Intelligence: The Evidence of Women’s Health

ObGyn Intelligence: The Evidence of Women’s Health

The Prevention Files

The MedMal Room: Oxytocin and VBAC - When Induction Turns Catastrophic

A new multicenter study quietly confirms what experience has long warned: oxytocin and prior cesarean scars are a dangerous mix.

Amos Grünebaum, MD's avatar
Amos Grünebaum, MD
Nov 06, 2025
∙ Paid

In obstetrics, few drugs are as paradoxical as oxytocin. It brings life into the world—and sometimes, it ends it. A new Obstetrics & Gynecology study by Bruno and colleagues (2025) should stop every clinician in their tracks:

during a trial of labor after cesarean (TOLAC), the risk of uterine rupture was nearly five to ten times higher when oxytocin was…

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